Program

Demonstration surgeries otology
Prof. Henryk Skarżyński, Prof. Piotr H. Skarżyński, Dr. Marek Porowski, Dr. Maciek Mrówka, Dr. Andrzej Pastuszak (Institute of Physiology and Pathology of Hearing)

Med-El

Moderators: Anna Rita Fetoni, Artur Lorens, Martyna Brylka

[12:10-12:40] Invited Lecture History of the Inner Ear Biology Meeting, Hans-Peter Zenner (University of Tübingen)

[12:40-12:55] Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs, Alan Cheng (Stanford University School of Medicine)

[12:55-13:10] The functional integrity of the mechanoelectrical transduction complex in the hair cells of the mature cochlea requires MYO7A, Samuel Webb (University of Sheffield)

[13:10-13:25] PHOENIX – An animal free platform to accelerate the development of new therapeutics against sensorineural hearing loss, Francis Rousset (University of Geneva)

[13:25-13:40] Intracochlear administration methods across species, Marion Souchal (Cilcare)

Moderators: Alan Cheng, Joanna Beck, Tuuli Lankinen, Tetiana Gołubok-Abyzova

[14:30-15:00] Invited Lecture, Cellular senescence in inner ear physiology and disease,  Isabel Varela Nieto (Superior Council for Scientific Research, Madrid)

[15:00-15:15] EDNRB2 is a novel marker for hair cell precursors in chick auditory epithelia, Mami Matsunaga (Kyoto University)

[15:15-15:30] HMGA2 mediates tonotopic identity in the developing mouse cochlea, Joerg Waldhaus (University of Michigan)

[15:30-15:45] Loud low frequency sound-induced pathophysiology of cochlear sound transmission and sound transduction, Wajiha Zaidi (Linköping University)

[15:45-16:00] Ageing, noise, and ER stress: Exploring stereocilia fusion pathology in the cochlear outer hair cells with super-resolution expansion microscopy, Kuu Ikäheimo (University of Helsinki)

Moderators: Isabel Varela Nieto, Samuel Webb, Adam Walkowiak

[16:10-16:40] Invited Lecture The cognitive ear: the emerging role in the aging, Anna Rita Fetoni (University of Naples Federico II)

[16:40-16:55] Assessing the cognitive decline post hearing loss, Sriram Hemachandran (Stanford University)

[16:55-17:10]  Investigating the genetic bases of age-related hearing loss – Human GWAS to mouse models, Carlos Aguilar (UCL Ear Institute)

[17:10-17:25] Discovery of NOX3 inhibitors for the prevention of acquired hearing loss, Lucie Oberhauser (University of Geneva Faculty of Medicine)

[17:25-17:40] NEUROD1 orchestrates cell fate changes and neurogenesis, Gabriela Pavlinkova (Institute of Biotechnology, Czech Academy of Sciences)

[17:40-17:55] Sensory transduction plays an essential role in the maturation of inner hair cells, afferent ribbon synapses and auditory nerve fibers, Thibault Peineau (Boston Children’s Hospital)

‘Friends Forever’ Ceremony

Networking Meeting at the ‘Pod Slimakiem’ Restaurant

Moderators: Bohua Hu, W. Wiktor Jedrzejczak, Aleksandra Kołodziejak

[08:00-08:15] Lgr5+ endogenous progenitor cells in the adult (deafened) cochlea, Natalia Smith-Cortinez (University Medical Center Utrecht)

[08:15-08:30]  A Mouse Model of Unilateral Stereotactic Radiosurgery-Induced Hearing Loss, Dimitrios Daskalou (University of Geneva Faculty of Medicine)

[08:30-08:45] Styrene ototoxicity is associated with memory impairment and hippocampal dysfunctions, Raffaele Montuoro (Università Cattolica del Sacro Cuore, Rome)

[08:45-09:00] Epigenetic landscape of supporting cell reprogramming toward hair cell regeneration in chick auditory epithelia, Takayuki Nakagawa (Kyoto University)

[09:00-09:15] Biosafety and biodistribution study of vesicle-enriched secretome fractions in cochlear implantation trauma, Athanasia Warnecke (Hannover Medical School)

Selected Problems of the Inner Ear Physiology and Pathology

Chairman: Henryk Skarżyński

Moderators: Piotr H. Skarżyński and Milaine Dominici Sanfins

Panelists:  Johathan Gale, Anna Rita Fetoni, Hashir Aazh, Agnes Szczepek, Monika Ołdak, Artur Lorens, Dimitros Daskalou, Alan Cheng, Renjie Chai

[09:20-09:35] Introduction to Round Table 1, Henryk Skarżyński (Institute of Physiology and Pathology of Hearing)

[09:35-10:55] Discussion

Moderators: Joerg Waldhaus, Kuu Ikäheimo, Anna Sztabnicka

[11:10-11:40] Invited Lecture, Identification of feedforward/feedback contributions to age-dependent hearing loss and tinnitus using OPM-MEG, Marlies Knipper (University of Tübingen)

[11:40-11:55] Whole organ imaging of the mature and aged mammalian vestibular system, Anthony Peng (University of Colorado Anschutz Medical Campus)

[11:55-12:10] In situ 3D fluorescence microscopy mapping in the Prphp-mCherry mouse line differentiates inner ear afferent populations, Lily Pearson (University of New South Wales in Sydney)

[12:10-12:25] Mechanotransduction molecules regulate stereocilia membrane mechanics, Shefin George (Stanford University)

[12:25-12:40] From cells to cures: hiPSC-derived inner organoids and RNA therapy to resolve genetic hearing loss, Esther Fousert (Leiden University Medical Center)

[12:40-12:55] Quantitative RNA-Scope study of the expression patterns of Tcf/Lef transcription factors in the otocyst, Javier de Andres (UCL Ear Institute)

Moderators: Vincent Van Rompaey, Dominika Ozieblo, Magdalena Sosna, Natalia Baldyga

[14:00-14:30] Invited Lecture, Deciphering the genetic background of autosomal dominant hearing loss, Monika Ołdak (Institute of Physiology and Pathology of Hearing)

[14:30-14:45] AAV-OTOF Gene therapy for autosomal recessive deafness 9: a multicenter, multiage, non-randomized controlled intervention study, Renjie Chai (Southeast University, Nanjing)

[14:45-15:00] Causes of bilateral sensorineural hearing loss in 838 patients according to degree of progression of hearing loss, Mariko Kasuga (Shinshu University School of Medicine)

[15:00-15:15] Isolated early onset hearing impairment? Diagnosis of syndromic forms by whole genome sequencing, Margaux Serey Gaut (Hôpital Necker)

[15:15-15:30] 350 families’ whole genome sequencing in early onset hearing loss: the French Reference Centre’s experience, Margaux Serey Gaut (Hôpital Necker)

[15:30-15:45] Essential role of ISL1 in the development and survival of spiral ganglion neurons in the inner ear, Mitra Tavakoli (Charles University in Prague)

[15:45-16:00] The hidden truth of hereditary hearing loss: gaining insight into the genetic basis of non-syndromic mimics, Giorgia Girotto (Institute for Maternal and Child Health I.R.C.C.S. “Burlo Garofolo”)

Moderators: Gabriela Pavlinkova, Athanasia Warnecke, Małgorzata Pastucha

[16:15-16:45] Invited Lecture, Cochlear Stress Granules: potential regulators of stress and survival in the inner ear, Jonathan Gale (UCL Ear Institute)

[16:45-17:00] Can you hear without FIRE: The impact of microglia loss on cochlear function, Patrick Atkinson (Stanford University)

[17:00-17:15] Supporting cell responses to sensory cell damage: Novel insights from a quantitative analysis of cyclodextrin-induced ototoxicity in mice, Bohua Hu (University at Buffalo)

[17:15-17:30] Perilymph proteome in prelingual deafness, Monika Matusiak (Institute of Physiology and Pathology of Hearing)

[17:30-17:45] Alteration of the gut microbiome causes sensorineural hearing loss by increasing blood-labyrinth barrier permeability and cochlear inflammation through the gut-cochlear axis, Anna Pisani (Università Di Napoli Federico II)

[17:45-18:00] Cochlear health in a cohort of cochlear implant users carrying the p.Pro51Ser variant in the COCH gene (DFNA9): a cross-sectional study evaluating the changes in the electrically evoked compound action potential (eCAP), Vincent Van Rompaey (University of Antwerp)

Hotel Park Kajetany

Moderators: Agnes Szczepek, Gwenaelle Geleoc, Ewelina Bukato

[08:00 – 08:30] Invited Lecture: Irx3/5 null deletion in mice blocks cochlea-saccule segregation, Bernd Fritzsch (University of Nebraska Medical Center)

[08:30-08:45] Antisense oligonucleotides for dominantly inherited hearing impairment DFNA9: from cells models to humanized mice, Erik de Vrieze (Radboud University Medical Center)

[08:45-09:00] Zebrafish in vivo functional investigation of TBC1D24 linked with autosomal dominant hearing loss reveals structural and functional defects of the inner ear,  Anna Sarosiak (Institute of Physiology and Pathology of Hearing)

[09:00-09:15] Mapping human inner ear development: insights from single-nucleus transcriptomics, Wouter van der Valk (Leiden University Medical Center)

[09:15-09:30] AAV-mediated precision treatment of SchABE8e in the pou4f3Q113*/+ mouse model, Man Wang (Southeast University, Nanjing)

Moderators: Bernd Fritzsch, Monika Matusiak, Łukasz Plichta

[09:40 – 10:10] Invited Lecture: The resident mast cells are a component of the cochlear immune system, Agnes Szczepek (Charite Medical University Berlin)

[10:10-10:25] The pharmacological action of Pimozide on vestibular Type-I and Type-II hair cells, Giulia Cheli (University of Pavia)

[10:25-10:40] Novel antisense therapy for USH2A patients, Gwenaelle Geleoc (Boston Children’s Hospital)

[10:40-10:55] The expression and functional role of histamine receptor 3 in the mammalian inner ear c57BL/6 mice, Lingyi Kong (Charité Universitätsmedizin Berlin)

[10:55-11:10] Human pluripotent derived auditory neuron progenitors (LCTANP1) for the treatment of auditory neuropathy spectrum disorder, Ofer Wiser (Lineage Cell Therapeutics, Inc.)

[11:10-11:25] The border and inner-phalangeal cells are required to synchronize the calcium action potentials in developing inner hair cells, Piece Yen (University of Sheffield)

Moderators: Huib Versnel, Vaclav Vencovsky, Anna Ratuszniak

[11:40 – 12:10] Invited Lecture: The Impact of OAEs on Hearing Science and the Inner Ear Research, Stavros Hatzopoulos (University of Ferrara)

[12:10-12:25] Input ear impedance and eardrum energy reflectance variations related to increase in intracochlear and intracranial pressure, Teresa Botti (INAIL, Monte Porzio Catone)

[12:25-12:40] Extended high frequency thresholds and their association with otoacoustic emissions and demographic factors, W. Wiktor Jedrzejczak (Institute of Physiology and Pathology of Hearing)

[12:40-12:55] The effect of brain-derived neurotrophic factor and neurotrophin-3 on the auditory nerve response to cochlear implant stimulation, David Sly (Ear Science Institute)

[12:55-13:10]  Lef1 and Tcf7l2 are Wnt signalling effectors with contrasting functions during inner ear sensory organ formation, Magdalena Żak (UCL Ear Institute)

[13:10-13:25]  Development of a ouabain-induced hearing loss guinea pig model for preclinical efficacy assessment, Marianne Aincy (Cilcare)

Moderators: Stavros Hatzopoulos, Anita Obrycka, Magdalena Skarżyńska

[14:30 – 15:00] Invited Lecture: Chronic electrical stimulation may slow down deafness-induced neural degeneration but does not change responsiveness of the auditory nerve, Huib Versnel (University Medical Center Utrecht)

[15:00-15:15] Influence of impeded biomechanics after implantation, Artur Lorens (Institute of Physiology and Pathology of Hearing)

[15:15-15:30] Efficacy of cochlear implantation in patients with severe to profound hearing loss without prior hearing aid use, Arisa Oguchi (Shinshu University School of Medicine)

[15:30-15:45] The clinical effect of steroids on hearing preservation in PDT patients in cochlear implantation, Magdalena Skarżyńska (Center of Hearing and Speech Kajetany)

[15:45-16:00] Validation of a newly developed SPL Chirp for intracochlear ECochG measurement, Adam Walkowiak (Institute of Physiology and Pathology of Hearing)

[16:00-16:15] A one-year time course of electrocochleography in cochlear implant users, Imogen van Beurden (University Medical Center Utrecht)

Moderator: Piotr H. Skarżyński